2. Signaling Pathways
  3. Immunology/Inflammation
  4. NO Synthase
  5. eNOS Isoform
  6. eNOS Inhibitor

eNOS Inhibitor

eNOS Inhibitors (5):

Cat. No. Product Name Effect Purity
  • HY-18732A
    L-NMMA acetate
    		Inhibitor 98.58%
    L-NMMA acetate is a nitric oxide synthase inhibitor of all NOS isoforms including NOS1, NOS2, and NOS3. The Ki values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 µM, respectively.
  • HY-152536
    iNOS inhibitor-10
    		Inhibitor
    iNOS inhibitor-10 is an iNOS inhibitor (IC50: 65 nM). iNOS inhibitor-10 has antiproliferative effect against triple negative breast cancer cells.
  • HY-115410
    NG-Amino-L-arginine hydrochloride
    		Inhibitor
    NG-Amino-L-arginine hydrochloride induces inactivation of the citrulline-forming activity of the nNOS, iNOS, and eNOS isoforms with Ki values of 0.3 μM, 3 μM, and 2.5 μM, respectively.
  • HY-W484263
    hnNOS-IN-3
    		Inhibitor
    hnNOS-IN-3 (compound 39) is a selective nNOS inhibitor, with a Ki of 0.32 μM. The nNOS binding of hnNOS-IN-3 is competitive with L-arginine. The selectivity of hnNOS-IN-3 for nNOS versus iNOS (Ki=37 μM) and eNOS (Ki=9.4 μM) is 115-fold and 29-fold, respectively.
  • HY-135224
    1,4-PBIT dihydrobromide
    		Inhibitor
    1,4-PBIT (1,4-PB-ITU) dihydrobromide (compound 46) is a potent nitric oxide synthases (NOS) inhibitor, with Ki values of 7.6 nM, 360 nM, and 16 nM for the inducible (iNOS), endothelial (eNOS), and neuronal (nNOS) isozymes, respectively.